Pharmacokinetics of Total Thyroxine after Repeated Oral Administration of Levothyroxine Solution and its Clinical Efficacy in Hypothyroid Dogs

Abstract

BACKGROUND Oral levothyroxine (l-T4 ) supplementation is commonly used to treat hypothyroid dogs. OBJECTIVES Investigate the plasma profile and pharmacokinetics of total thyroxine (tT4 ) after PO administration of a l-T4 solution and its clinical efficacy in hypothyroid dogs. ANIMALS Ten dogs with naturally occurring hypothyroidism. METHODS After… (More)
DOI: 10.1111/jvim.12363

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