Pharmacokinetics of Taurolidine following Repeated Intravenous Infusions Measured by HPLC-ESI-MS/MS of the Derivatives Taurultame and Taurinamide in Glioblastoma Patients

@article{Stendel2007PharmacokineticsOT,
  title={Pharmacokinetics of Taurolidine following Repeated Intravenous Infusions Measured by HPLC-ESI-MS/MS of the Derivatives Taurultame and Taurinamide in Glioblastoma Patients},
  author={Ruediger Stendel and Louis Scheurer and Kathrin Schlatterer and Urs Stalder and Rolf Wilhelm Pfirrmann and Ingo Fiss and Hanns M. {\"o}hler and Laurent Bigler},
  journal={Clinical Pharmacokinetics},
  year={2007},
  volume={46},
  pages={513-524}
}
Background and objectiveTaurolidine is known to have antimicrobial activity. Furthermore, at lower concentrations, it has been found to exert a selective antineoplastic effect in vitro and in vivo. The aim of this study was to investigate the pharmacokinetics of taurolidine in vivo following repeated intravenous infusion in a schedule used for the treatment of glioblastoma. As a prerequisite, the pharmacokinetics of taurolidine in human blood plasma and whole blood in vitro was investigated… 

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