Pharmacokinetics of THC in brain and testis, male gametotoxicity and premature apoptosis of spermatozoa.

@article{Nahas2002PharmacokineticsOT,
  title={Pharmacokinetics of THC in brain and testis, male gametotoxicity and premature apoptosis of spermatozoa.},
  author={Gabriel G. Nahas and Henry Clay Frick and John K Lattimer and Colette Latour and David Harvey},
  journal={Human psychopharmacology},
  year={2002},
  volume={17 2},
  pages={103-13}
}
An earlier report described the pharmacokinetics of delta-9 THC and the resulting brain function responses. In the present studies the pharmacokinetics of THC in plasma, brain and testis were related to impairment of spermatogenesis. THC- containing preparations, whatever their route of administration, were associated with the induction of gametotoxicity in all species studied including man. The pharmacokinetics and molecular binding of THC is similar in all experimental models. Concentrations… CONTINUE READING

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