Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women.

@article{Tran2016PharmacokineticsOR,
  title={Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women.},
  author={Anna Thi Huyen Tran and Brookie M. Best and A. Stek and Jianbo Wang and Edmund Capparelli and Sandra K. Burchett and R{\'e}gis Kreitchmann and Kittipong Rungruengthanakit and Kathleen George and Tim R. Cressey and Nahida A Chakhtoura and Elizabeth Smith and David E. Shapiro and Mark H Mirochnick},
  journal={Journal of acquired immune deficiency syndromes},
  year={2016},
  volume={72 3},
  pages={
          289-96
        }
}
BACKGROUND Rilpivirine pharmacokinetics is defined by its absorption, distribution, metabolism, and excretion. Pregnancy can affect these factors by changes in cardiac output, protein binding, volume of distribution, and cytochrome P450 (CYP) 3A4 activity. Rilpivirine is metabolized by CYP3A4. The impact of pregnancy on rilpivirine pharmacokinetics is largely unknown. METHODS International Maternal Pediatric Adolescent AIDS Clinical Trials P1026s is a multicenter, nonblinded, prospective… CONTINUE READING

Citations

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Lowered Rilpivirine Exposure During the Third Trimester of Pregnancy in Human Immunodeficiency Virus Type 1-Infected Women.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2017
VIEW 6 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

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