Pharmacokinetics of Rectal Drug Administration, Part I

@article{Hoogdalem1991PharmacokineticsOR,
  title={Pharmacokinetics of Rectal Drug Administration, Part I},
  author={Ewoud J. van Hoogdalem and Albertus G. de Boer and D. D. Breimer},
  journal={Clinical Pharmacokinetics},
  year={1991},
  volume={21},
  pages={11-26}
}
SummaryGenerally, oral administration is the route of choice in the daily practice of pharmacotherapy. However, in some circumstances this is impractical or even impossible (during nausea and vomiting or convulsions, in uncooperative patients and before surgery). In these cases, the rectal route may represent a practical alternative and rectal administration is now well accepted for delivering, for example, anticonvulsants, non-narcotic and narcotic analgesics, theophylline, antiemetics and… 

Rectal Drug Administration

The relative bioavailability of metoprolol following oral and rectal administration to volunteers and patients

Metoprolol suppositories appear to be an effective, safe and suitable alternative for patients who are in need for beta blocking medication and who are unable to take oral medication for a certain amount of time.

Rectal Bioavailability of Sertraline Tablets in a Critically Ill Patient With Bowel Compromise.

The case of a 55-year-old woman in whom sertraline tablets were administered rectally for depression and anxiety and where PK monitoring was performed is described.

Pharmacokinetics and bioavailability of denaverine hydrochloride in healthy subjects following intravenous, oral and rectal single doses.

  • A. StaabB. Schug H. Blume
  • Medicine
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2003

Relative Bioavailability, Metabolism and Tolerability of Rectally Administered Oxcarbazepine Suspension

It is unlikely that adequate monohydroxy derivative concentrations can be achieved with rectal administration of diluted oxcarbazepine suspension, and the bioavailability, metabolism and tolerability of rectal and oral routes are characterised.

The suppository form of antibiotic administration: pharmacokinetics and clinical application.

The rectal route of antibiotic administration might be used effectively when other routes of administration are inadequate or unsuitable. With the use of various adjuvants, the rectal route can

Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers.

Sublingual administration of a single dose of tacrolimus does not result in systemic exposure if care is taken not to swallow saliva and to rinse the oral cavity afterwards, and rectal administration results in clinically relevant systemic exposure and might represent an alternative formulation in case oral administration is not feasible.

Drug Delivery on Rectal Absorption : Suppositories

The rate and extent of rectal drug absorption are often lower than with oral absorption possibly an inherent factor owing to the relatively small surface area available for drug uptake.

Achievements in Thermosensitive Gelling Systems for Rectal Administration

A novel rectal drug delivery system is introduced with the goal of summarising recent developments in thermosensitive liquid suppositories for analgesic, anticancer, antiemetic, antihypertensive, psychiatric, antiallergic, anaesthetic, antimalarial drugs and insulin.
...