Pharmacokinetics of Propofol in Adult Patients Undergoing Coronary Revascularization
@article{Bailey1996PharmacokineticsOP, title={Pharmacokinetics of Propofol in Adult Patients Undergoing Coronary Revascularization}, author={James M. Bailey and Christina T. Mora and Steven L. Shafer}, journal={Anesthesiology}, year={1996}, volume={84}, pages={1288–1297.} }
Background Propofol is increasingly used for cardiac anesthesia and for perioperative sedation. Because pharmacokinetic parameters vary among distinct patient populations, rational drug dosing in the cardiac surgery patient is dependent on characterization of the drug's pharmacokinetic parameters in patients actually undergoing cardiac procedures and cardiopulmonary bypass (CPB). In this study, the pharmacokinetics of propofol was characterized in adult patients undergoing coronary…
74 Citations
Effects of Cardiopulmonary Bypass on Propofol Pharmacokinetics and Bispectral Index During Coronary Surgery
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References
SHOWING 1-10 OF 24 REFERENCES
Pharmacokinetics of an infusion of propofol during cardiac surgery.
- Medicine, BiologyBritish journal of anaesthesia
- 1990
Volume of distribution, clearance and terminal half-life were similar to those found in non-cardiac patients when propofol was administered as a constant rate infusion during cardiac surgery.
Myocardial metabolic and hemodynamic changes during propofol anesthesia for cardiac surgery in patients with reduced ventricular function.
- Medicine, BiologyAnesthesia and analgesia
- 1993
This study examined the hypothesis that the use of propofol for induction and maintenance of anesthesia in patients with reduced ejection fraction (< 0.5) undergoing coronary artery revascularization…
Pharmacokinetics and Pharmacodynamics of Propofol Infusions during General Anesthesia
- Medicine, BiologyAnesthesiology
- 1988
This clinical study demonstrates the feasibility of performing pharmacokinetic and pharmacodynamic analyses when complex infusion and bolus regimens are used for administering iv anesthetics.
Disposition of Propofol Administered as Constant Rate Intravenous Infusions in Humans
- Biology, MedicineAnesthesia and analgesia
- 1987
The disposition of the intravenous anesthetic propofol was studied when administered as a constant rate infusion at 3, 6, and 9 mg·kg1·hr−1 for at least 2 hr to three groups of six patients each undergoing surgery under regional anesthesia to appear linear over the dosage range studied.
Total intravenous anesthesia using propofol and alfentanil for coronary artery bypass surgery.
- MedicineJournal of cardiothoracic and vascular anesthesia
- 1994
Propofol—fentanyl anaesthesia for coronary artery surgery and cardiopulmonary bypass
- Medicine, BiologyAnaesthesia
- 1989
A two‐stage propofol infusion combined with fentanyl was wed to maintain anaesthesia during coronary artery surgery in patients with good ventricular function and no patient had any recall of operative events or required inotropic support during weaning from bypass.
The Pharmacokinetics of Propofol in Children Using Three Different Data Analysis Approaches
- Medicine, BiologyAnesthesiology
- 1994
The pharmacokinetics of propofol in children are well described by a standard three-compartment pharmacokinetic model and weight was a significant covariate, and the weight-proportional model was supported by all three regression approaches.
Pharmacokinetics of fentanyl administered by computer-controlled infusion pump.
- Medicine, BiologyAnesthesiology
- 1990
A pharmacokinetics study using a CCIP may be particularly effective at characterizing the most rapid distribution pharmacokinetic parameters, and thus may provide parameters appropriate for subsequent use in aCCIP.
Left Ventricular Function during Propofol and Fentanyl Anesthesia in Patients with Coronary Artery Disease: Assessment with a Radionuclide Approach
- Medicine, BiologyAnesthesia and analgesia
- 1988
Propofol alone and in combination with fentanyl does not alter LV performance in patients with good LV function, however, the magnitude of MAP reduction might jeopardize coronary perfusion in severe ischemic heart disease.
Pharmacokinetic model selection for target controlled infusions of propofol. Assessment of three parameter sets.
- Medicine, Biology
- 1994
Clinically, TCI worked well, and by clinical criteria, the choice of pharmacokinetic model did not appear to make a difference, but it is acceptable to use a model from elsewhere.