Pharmacokinetics of Propofol in Adult Patients Undergoing Coronary Revascularization

@article{Bailey1996PharmacokineticsOP,
  title={Pharmacokinetics of Propofol in Adult Patients Undergoing Coronary Revascularization},
  author={James M. Bailey and Christina T. Mora and Steven L. Shafer},
  journal={Anesthesiology},
  year={1996},
  volume={84},
  pages={1288–1297.}
}
Background Propofol is increasingly used for cardiac anesthesia and for perioperative sedation. Because pharmacokinetic parameters vary among distinct patient populations, rational drug dosing in the cardiac surgery patient is dependent on characterization of the drug's pharmacokinetic parameters in patients actually undergoing cardiac procedures and cardiopulmonary bypass (CPB). In this study, the pharmacokinetics of propofol was characterized in adult patients undergoing coronary… 
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74 Citations
Background Citations
12
Methods Citations
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74 Citations

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Citation Type

Effects of Cardiopulmonary Bypass on Propofol Pharmacokinetics and Bispectral Index During Coronary Surgery
TLDR
Aside from the increased sensitivity of the brain to anesthetics after cardiopulmonary bypass, changes in propofol pharmacokinetics may contribute to its central nervous system effects.
Validation of fentanyl pharmacokinetics in patients undergoing coronary artery bypass grafting
TLDR
A pharmacokinetic model that accurately predicts fentanyl concentrations before, during, and after cardiopulmonary bypass in patients undergoing coronary artery bypass grafting (CABG) provides a rational foundation for designing fentanyl dose regimens for patients undergoing CABG.
Obesity Does Not Affect Propofol Pharmacokinetics During Hypothermic Cardiopulmonary Bypass.
TLDR
Propofol pharmacokinetic parameters were similar in obese and nonobese patients undergoing hypothermic CPB and age was the major determinant of propofol V2 in the obese population.
Pharmacokinetics of Propofol Administered by Target-controlled Infusion to Alcoholic Patients
TLDR
Propofol pharmacokinetics are markedly different during anesthesia and surgery or after opening eyes in the recovery period, compared with control patients, which indicates that chronic alcoholism induces only mild changes in the Pharmacokinetics of propofol.
Cardiopulmonary Bypass Has Minimal Effects on the Pharmacokinetics of Fentanyl in Adults
TLDR
The effect of CPB on fentanyl kinetics is clinically insignificant and a simple three-compartment model accurately predicts fentanyl concentrations throughout surgery using CPB is selected.
Effects of Cardiopulmonary Bypass on Sufentanil Pharmacokinetics in Patients Undergoing Coronary Artery Bypass Surgery
TLDR
It is suggested that cardiopulmonary bypass has clinically insignificant effects on sufentanil kinetics in adults, as compared with a simple, three-compartment model.
Impact of Bispectral Index Monitoring on Propofol Administration in Patients Undergoing Cardiopulmonary Bypass
TLDR
Bispectral index monitoring enables a 50% reduction in propofol administration at this standard dose during hypothermic cardiopulmonary bypass, reflecting a deeper state of anaesthesia.
Proper Target Concentration of Fentanyl during Endotracheal Intubation with a CACI (Computer Assisted Continuous Infusion) in Patients Undergoing Coronary Artery Bypass Graft Surgery
TLDR
It is reasonable to say that the lower dose of fentanyl (5 ng/ml) may be the better choice, because it provides the same level of anesthesia during endotracheal intubation during coronary artery bypass graft surgery.
Comparison of two different anesthesia regimens in patients undergoing aortocoronary bypass grafting surgery: sufentanil-midazolam versus remifentanil-propofol.
TLDR
Both anesthesia regimens provided stable hemodynamics and adequate anesthesia in patients undergoing coronary artery bypass graft surgery.
The current role of total intravenous anesthesia in cardiac surgery: total intravenous anesthesia and cardiopulmonary bypass.
  • S. Schraag
  • Medicine
    Journal of cardiothoracic and vascular anesthesia
  • 2015
TLDR
With the availability of newer and shorter acting intravenous (IV) and volatile anesthetic agents, cardiac anesthesia fundamentally has shifted from a high-dose opioid/narcotic technique in recent years to a more balanced, synergistic approach.
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