Pharmacokinetics of Propofol in Adult Patients Undergoing Coronary Revascularization

@article{Bailey1996PharmacokineticsOP,
  title={Pharmacokinetics of Propofol in Adult Patients Undergoing Coronary Revascularization},
  author={James M. Bailey and Christina T. Mora and Steven L. Shafer},
  journal={Anesthesiology},
  year={1996},
  volume={84},
  pages={1288–1297.}
}
Background Propofol is increasingly used for cardiac anesthesia and for perioperative sedation. Because pharmacokinetic parameters vary among distinct patient populations, rational drug dosing in the cardiac surgery patient is dependent on characterization of the drug's pharmacokinetic parameters in patients actually undergoing cardiac procedures and cardiopulmonary bypass (CPB). In this study, the pharmacokinetics of propofol was characterized in adult patients undergoing coronary… 
Effects of Cardiopulmonary Bypass on Propofol Pharmacokinetics and Bispectral Index During Coronary Surgery
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The current role of total intravenous anesthesia in cardiac surgery: total intravenous anesthesia and cardiopulmonary bypass.
  • S. Schraag
  • Medicine
    Journal of cardiothoracic and vascular anesthesia
  • 2015
TLDR
With the availability of newer and shorter acting intravenous (IV) and volatile anesthetic agents, cardiac anesthesia fundamentally has shifted from a high-dose opioid/narcotic technique in recent years to a more balanced, synergistic approach.
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