Pharmacokinetics of Prophylactic Indomethacin in Very Low-birthweight Premature Infants


The pharmacokinetics of indomethacin (I) was assessed in infants who received prophylactic (I) for patent ductus arteriosus (PDA). The first dose (0.2 mg/kg), given within 12 hours after birth, was followed by two q 12 hourly doses (0.1 mg/kg). The mean birth weight (BW) of these infants was 923 ± 134.0 gm (range: 730-1070gm) with a mean gestational age of… (More)
DOI: 10.1203/00006450-198404001-00407