Pharmacokinetics of Pregabalin in Subjects with Various Degrees of Renal Function

@article{Randinitis2003PharmacokineticsOP,
  title={Pharmacokinetics of Pregabalin in Subjects with Various Degrees of Renal Function},
  author={Edward J. Randinitis and Edward L. Posvar and Christine W. Alvey and Allen J. Sedman and Jack Cook and Howard N. Bockbrader},
  journal={The Journal of Clinical Pharmacology},
  year={2003},
  volume={43}
}
The objectives of this study were to determine the single‐dose pharmacokinetics of pregabalin in subjects with various degrees of renal function, determine the relationship between pregabalin clearance and estimated creatinine clearance (CLcr), and measure the effect of hemodialysis on plasma levels of pregabalin. Results form the basis of recommended pregabalin dosing regimens in patients with decreased renal function. Thirty‐eight subjects were enrolled to ensure a wide range of renal… 
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Half of usual starting and maintenance dose is recommended in moderate-severe renal impairment patients, and those with ESRD and severe renal impairment, while supplemental dose may be required during hemodialysis.
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