Pharmacokinetics of Pegylated Liposomal Doxorubicin

@article{Gabizon2003PharmacokineticsOP,
  title={Pharmacokinetics of Pegylated Liposomal Doxorubicin},
  author={A. Gabizon and H. Shmeeda and Y. Barenholz},
  journal={Clinical Pharmacokinetics},
  year={2003},
  volume={42},
  pages={419-436}
}
Pegylated liposomal doxorubicin (doxorubicin HCl liposome injection; Doxil® or Caelyx®) is a liposomal formulation of doxorubicin, reducing uptake by the reticulo-endothelial system due to the attachment of polyethylene glycol polymers to a lipid anchor and stably retaining drug as a result of liposomal entrapment via an ammonium sulfate chemical gradient. These features result in a pharmacokinetic profile characterised by an extended circulation time and a reduced volume of distribution… Expand
The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin.
Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations.
Allometric scaling of pegylated liposomal anticancer drugs
Direct comparison of two pegylated liposomal doxorubicin formulations: is AUC predictive for toxicity and efficacy?
Interaction of liposomes bearing a lipophilic doxorubicin prodrug with tumor cells
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