Pharmacokinetics of N3-Benzylthymidine Possessing Hypnotic Activity in Mice

  title={Pharmacokinetics of N3-Benzylthymidine Possessing Hypnotic Activity in Mice},
  author={E. Furuta and T. Kimura and M. Koshigami and Jiro Kuze and Kazuhito Watanabe and I. Yamamoto},
  journal={Drug Metabolism and Pharmacokinetics},
  • E. Furuta, T. Kimura, +3 authors I. Yamamoto
  • Published 1992
  • Chemistry
  • Drug Metabolism and Pharmacokinetics
  • The pharmacological potency, absorption, distribution and excretion of N3-benzylthymidine (N3-ByTd), a new type of hypnotics, were studied in mice. N3-Substituted thymidine derivative, N3-o, m or p-xylylthymidine, N3-m-chlorobenzylthymidine, were synthesized. Furthermore, the sugar moiety of certain derivatives was methylated. N3-ByTd and its derivatives were evaluated for hypnotic activity by intracerebroventricular (i.c.v.) administration as central depressants. N3-ByTd (2.0μmol/mouse… CONTINUE READING
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