Pharmacokinetics of N-acetylcysteine in man

@article{Borgstrm2004PharmacokineticsON,
  title={Pharmacokinetics of N-acetylcysteine in man},
  author={Lars Borgstr{\"o}m and Bertil K{\aa}gedal and Otto Paulsen},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={31},
  pages={217-222}
}
SummaryN-Acetylcysteine was given intravenously and as three fast dissolving and one slow-release formulation, on separate occasions, as a single dose of 600 mg to 10 fasting (5 men and 5 women) healthy volunteers. Blood and urine were sampled for the following 12 h.Renal clearance constituted around 30% of total body clearance, which was 0.21 l/h/kg. Volume of distribution was 0.33 l/kg, consistent with distribution mainly to extracellular water. The late elimination half-life was 2.27 h and… 
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