Pharmacokinetics of Methadone

@article{Lugo2005PharmacokineticsOM,
  title={Pharmacokinetics of Methadone},
  author={Ralph A. Lugo and Kristin Satterfield and Steven Edward Kern},
  journal={Journal of Pain \& Palliative Care Pharmacotherapy},
  year={2005},
  volume={19},
  pages={13 - 24}
}
Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes. The pharmacokinetics of methadone are variable and an understanding of the factors that impact the onset, magnitude, and duration of analgesia is required to optimize… 
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