Pharmacokinetics of Meropenem in Patients with Cystic Fibrosis

  title={Pharmacokinetics of Meropenem in Patients with Cystic Fibrosis},
  author={Bertil Christensson and Bengt Ljungberg and L. -O. Eriksson and Ingrid Nilsson-Ehle},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
 The pharmacokinetics of meropenem were studied after single i.v. infusions of 15 mg meropenem/kg body weight in eight subjects with cystic fibrosis (CF) and eight healthy volunteers matched for age, sex, and weight. Significantly shorter terminal half-lives (mean, 0.74 h vs. 0.99 h) and mean residence times (mean, 1.09 h vs. 1.39 h) were noted in CF subjects. Plasma and renal clearances tended to be higher and distribution volumes smaller among the patients, but differences were not… CONTINUE READING

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