Pharmacokinetics of Intravenous Ibuprofen

  title={Pharmacokinetics of Intravenous Ibuprofen},
  author={Howard S. Smith and Bryan Voss},
Intravenous NSAIDs are playing an increasingly large role in analgesia, anti-inflammation and antipyresis in the hospitalized setting. [] Key Method The pharmacokinetic profile of the following doses was modelled: 30-minute infusion of 800 mg intravenous ibuprofen, 5- to 7-minute infusion of 400 mg intravenous ibuprofen and 400 mg ibuprofen oral tablet. These pharmacokinetic analyses revealed that, in general, maximum plasma concentration (Cmax) decreases considerably as the length of the infusion increases…
Pharmacokinetic Properties of Intravenous Ibuprofen in Healthy Chinese Volunteers
Similar pharmacokinetic properties of intravenous ibuprofen in healthy Chinese volunteers were observed to those reported in a Caucasian population.
Intravenous Ibuprofen
In three double-blind, multicentre trials in postoperative adult patients, intravenous ibuprofen 800 mg once every 6 hours, as an adjunct to morphine, significantly reduced the consumption of morphine compared with placebo in two of the three trials; the between-group difference attained statistical significance in the third trial utilizing a Log-rank transformed analysis.
Rectal Administration of Ibuprofen: Comparison of Enema and Suppository Form.
The pharmacokinetic parameters of rectal administration of ibuprofen between enema and suppository form were compared in order to provide evidence for the faster absorption rates of ib uprofen enema to provide faster onset of analgesic and antipyretic benefit.
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.
It is experimentally shown that the in vivo intestinal dissolution of ibuprofen is dependent upon physiological variables like pH and postdose phase III contractions, and this work presents a thorough statistical analysis explaining how the GI behavior of an ionized drug can explain the systemic exposure of the drug based on the individual profiles of participating subjects.
Comparison of Monotherapy Versus Combination of Intravenous Ibuprofen and Propacetamol (Acetaminophen) for Reduction of Postoperative Opioid Administration in Children Undergoing Laparoscopic Hernia Repair: A Double-Blind Randomized Controlled Trial.
The use of ibuprofen plus propacetamol immediately following laparoscopic hernia repair surgery in children resulted in the reduced use of an opioid drug compared with the use of propacetAMol alone.
IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.
The current study provides encouraging, but only very weak evidence that IV ibuprofen decreases PEP in children, and suggests that a small handful of high-volume pediatric centers would be able to perform an adequate clinical trial in a reasonable time frame.


Intravenous ibuprofen: the first injectable product for the treatment of pain and fever
The clinical utility of a parenteral NSAID in a hospitalized patient for post-operative pain management and fever reduction is addressed, and further data on intravenous ibuprofen are needed to define long-term utilization, management of acute pain, and use in special populations.
Pharmacokinetics, safety, and tolerability of a rapid infusion of i.v. ibuprofen in healthy adults.
  • L. Pavliv, Bryan Voss, A. Rock
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2011
I.V. ibuprofen, when administered over five to seven minutes in healthy subjects, achieved a higher C(max) and a more-rapid t( max) than did oral ib uprofen and was found to be safe and well tolerated.
Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man.
Drug tolerability was excellent for the oral administration of ib uprofen lysine as well as for the intravenous treatments with ibuprofen free acid, and from the results of intravenous injections one can deduce linear ibup rofen pharmacokinetics within the considered dosage range.
Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children
Temperature reduction for the ib uprofen dose was significantly different than that of the acetaminophen dose at later time points, and further pharmacokinetic‐pharmacodynamic studies with use of individual ibuprofen stereoisomers and other dosing regimens are indicated.
Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia.
IV-ibuprofen was effective and well tolerated in reducing fever in febrile inpatients with malaria and parasite clearance was delayed in the patients whose fevers were controlled by IV-ib uprofen.
Activity and pharmacokinetics of a new oral dosage form of soluble ibuprofen.
The results showed that the soluble granular form is able to determine an analgesic effect significantly quicker and higher than that of tablets, according to a single dose, double-blind cross-over balanced design.
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group.
Treatment with ibuprofen reduces levels of prostacyclin and thromboxane and decreases fever, tachycardia, oxygen consumption, and lactic acidosis, but it does not prevent the development of shock or the acute respiratory distress syndrome and does not improve survival.
Onset of Analgesia for Liquigel Ibuprofen 400 mg, Acetaminophen 1000 mg, Ketoprofen 25 mg, and Placebo in the Treatment of Postoperative Dental Pain
Liquigel ib uprofen 400 mg was shown to provide faster relief and superior overall efficacy compared with ketoprofen 25 mg, acetaminophen 1000 mg, and placebo, and ibuprofen was significantly better than both acetaminphen and ketop rofen.
Effect of age on ibuprofen pharmacokinetics and antipyretic response.