Pharmacokinetics of Intravenous Ibuprofen

@article{Smith2012PharmacokineticsOI,
  title={Pharmacokinetics of Intravenous Ibuprofen},
  author={H. Smith and Bryan Voss},
  journal={Drugs},
  year={2012},
  volume={72},
  pages={327-337}
}
  • H. Smith, Bryan Voss
  • Published 2012
  • Medicine
  • Drugs
  • Intravenous NSAIDs are playing an increasingly large role in analgesia, anti-inflammation and antipyresis in the hospitalized setting. [...] Key Method The pharmacokinetic profile of the following doses was modelled: 30-minute infusion of 800 mg intravenous ibuprofen, 5- to 7-minute infusion of 400 mg intravenous ibuprofen and 400 mg ibuprofen oral tablet. These pharmacokinetic analyses revealed that, in general, maximum plasma concentration (Cmax) decreases considerably as the length of the infusion increases…Expand Abstract

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