Corpus ID: 27409986

Pharmacokinetics of Injectable Beta - Cyclodextrin - Oridonin Inclusion Complex, A Novel Formulation of Oridonin in Wistar Rats

@article{Li2012PharmacokineticsOI,
  title={Pharmacokinetics of Injectable Beta - Cyclodextrin - Oridonin Inclusion Complex, A Novel Formulation of Oridonin in Wistar Rats},
  author={Bqoqu Li and N. Li and Shujuan Wang},
  journal={National Journal of Physiology, Pharmacy and Pharmacology},
  year={2012},
  volume={2},
  pages={52-57}
}
Aims: Oridonin is a new anti-tumor drug candidate with promising broad spectrum antitumor activity. The aim of the present study is to investigate the single- and repeated-dose pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complexin rats. Materials and methods: Rats were given single- or multiple-dose (7 days) of injectable beta-cyclodextrin-oridonin inclusion complex (single-dose: 33 mg/m2, 99 mg/m2, 296 mg/m2; repeatede-dose: 99 mg/m2 calculated as oridonin) by… Expand
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References

SHOWING 1-10 OF 23 REFERENCES
Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma
  • 39
  • PDF
In vitro and in vivo antitumor activity of oridonin nanosuspension.
  • 61
The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells.
  • 53
[Empirical study of oridonin-induced gastric cancer cells MKN45 apoptosis].
  • 8
Oridonin-induced apoptosis in leukemia K562 cells and its mechanism.
  • 20
Liposomal doxorubicin and nab-paclitaxel: nanoparticle cancer chemotherapy in current clinical use.
  • 57
Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling
  • 17
  • PDF
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3
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