Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication

@inproceedings{Sugarbaker2012PharmacokineticsOH,
  title={Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication},
  author={Paul H Sugarbaker and Oswald Anthony Stuart and Christopher Eger},
  booktitle={Gastroenterology research and practice},
  year={2012}
}
In patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space. We monitored the intrapleural and plasma levels of mitomycin C and doxorubicin by HPLC assay in order to determine the pharmacokinetic behavior of this intracavitary use of chemotherapy. Our results showed a persistent high concentration of intrapleural drug as compared to plasma concentrations. The… CONTINUE READING

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