Pharmacokinetics of Haloperidol

@article{Kudo1999PharmacokineticsOH,
  title={Pharmacokinetics of Haloperidol},
  author={Shoji Kudo and Takashi Ishizaki},
  journal={Clinical Pharmacokinetics},
  year={1999},
  volume={37},
  pages={435-456}
}
AbstractHaloperidol is commonly used in the therapy of patients with acute and chronic schizophrenia. The enzymes involved in the biotransformation of haloperidol include cytochrome P450 (CYP), carbonyl reductase and uridine diphosphoglucose glucuronosyltransferase.The greatest proportion of the intrinsic hepatic clearance of haloperidol is by glucuronidation, followed by the reduction of haloperidol to reduced haloperidol and by CYP-mediated oxidation. In studies of CYP-mediated disposition in… CONTINUE READING

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