Pharmacokinetics of Glutamate–Oxaloacetate Transaminase and Glutamate–Pyruvate Transaminase and Their Blood Glutamate-Lowering Activity in Naïve Rats

@article{Boyko2012PharmacokineticsOG,
  title={Pharmacokinetics of Glutamate–Oxaloacetate Transaminase and Glutamate–Pyruvate Transaminase and Their Blood Glutamate-Lowering Activity in Na{\"i}ve Rats},
  author={Matthew Boyko and David Stepensky and Benjamin Fredrick Gruenbaum and Shaun E Gruenbaum and Israel Melamed and Sharon Ohayon and Michael Glazer and Yoram Shapira and Alexander A. Zlotnik},
  journal={Neurochemical Research},
  year={2012},
  volume={37},
  pages={2198-2205}
}
Traumatic brain injury (TBI) and stroke lead to elevated levels of glutamate in the brain that negatively affect the neurological outcomes in both animals and humans. Intravenous administration of glutamate–oxaloacetate transaminase (GOT) and glutamate–pyruvate transaminase (GPT) enzymes can be used to lower the blood glutamate levels and to improve the neurological outcome following TBI and stroke. The objective of this study was to analyze the pharmacokinetics and to determine the glutamate… CONTINUE READING
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