Pharmacokinetics of Efavirenz dosed according to the WHO weight-bands in children in Uganda.

@inproceedings{BakeeraKitaka2010PharmacokineticsOE,
  title={Pharmacokinetics of Efavirenz dosed according to the WHO weight-bands in children in Uganda.},
  author={Sabrina Bakeera-Kitaka and Lindsay Kendall and Eva Natukunda and Quirine Fillekes and Adeodata Kekitiinwa and Christopher Tumusiime and Peter Mugyenyi and Anne Sarah Walker and Diana M. Gibb and Dm Burger and Arrow},
  year={2010}
}
Background: Efavirenz (EFV) is commonly used in children over 3 years worldwide, but there is only limited pharmacokinetic (PK) information available in African children. Methods: 41 HIV-infected Ugandan children aged 3-12 years on generic EFV plus 3TC+ABC were enrolled in a cross-over PK study of twice to once daily 3TC+ABC 36 weeks after ART initiation in the ARROW trial. Once-daily EFV doses following WHO weight-bands were 200/250/300*/350* mg for children weighing 10-15/15-20/20-25/25-30kg… CONTINUE READING