Pharmacokinetics of Deramciclane, a Novel Anxiolytic Agent, after Intravenous and Oral Administration

@article{Huupponen2003PharmacokineticsOD,
  title={Pharmacokinetics of Deramciclane, a Novel Anxiolytic Agent, after Intravenous and Oral Administration},
  author={Risto K. Huupponen and Outi Paija and Markku Salonen and Harry Bj{\"o}rklund and Juha Rouru and Markku I. Anttila},
  journal={Drugs in R \& D},
  year={2003},
  volume={4},
  pages={339-345}
}
AbstractBackground and objective: Deramciclane is a new compound that has shown anxiolytic effects in animal experiments and in human studies. The aim of this study was to determine the pharmacokinetic parameters of deramciclane after intravenous and oral administration, and its oral bioavailability. Methods: Deramciclane 30mg was given intravenously and orally as a tablet and as solution in an open, randomised, crossover three-period trial to 12 healthy male volunteers. Oral bioavailability… 
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Synthesis of deramciclane* labeled with tritium in various positions

[(1R)-endo]-(+)-3-bromocamphor was dehalogenated with tritium gas to [3-3H]camphor and via [3-3H]phenylborneol converted to [3-3H]deramciclane isolated as the fumarate salt (specific activity 51.8

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