Pharmacokinetics of Deramciclane, a Novel Anxiolytic Agent, after Intravenous and Oral Administration

@article{Huupponen2003PharmacokineticsOD,
  title={Pharmacokinetics of Deramciclane, a Novel Anxiolytic Agent, after Intravenous and Oral Administration},
  author={R. Huupponen and O. Paija and M. Salonen and Harry Bj{\"o}rklund and J. Rouru and M. Anttila},
  journal={Drugs in R \& D},
  year={2003},
  volume={4},
  pages={339-345}
}
AbstractBackground and objective: Deramciclane is a new compound that has shown anxiolytic effects in animal experiments and in human studies. The aim of this study was to determine the pharmacokinetic parameters of deramciclane after intravenous and oral administration, and its oral bioavailability. Methods: Deramciclane 30mg was given intravenously and orally as a tablet and as solution in an open, randomised, crossover three-period trial to 12 healthy male volunteers. Oral bioavailability… Expand
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