Pharmacokinetics of Coadministered Guanfacine Extended Release and Lisdexamfetamine Dimesylate

  title={Pharmacokinetics of Coadministered Guanfacine Extended Release and Lisdexamfetamine Dimesylate},
  author={Benno G Roesch and Mary E. Corcoran and Jennifer Fetterolf and Mary B. Haffey and Patrick T. Martin and P. Preston and Jaideep Purkayastha and Phillip Wang and James C. Ermer},
  booktitle={Drugs in R&D},
BACKGROUND In clinical practice, α₂-adrenoceptor agonists have been adjunctively administered with psychostimulants for the treatment of attention-deficit/hyperactivity disorder (ADHD). Two studies have examined the adjunctive use of guanfacine extended release (GXR, Intuniv®; Shire Development LLC, Wayne, PA, USA) with psychostimulants in children and adolescents with a suboptimal response to psychostimulant treatment. However, the potential for pharmacokinetic drug-drug interactions (DDIs… CONTINUE READING
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Concerta (package insert)

  • B. Roesch
  • Titusville: McNeil Pediatrics;
  • 2010

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