Pharmacokinetics of Captopril in Healthy Subjects and in Patients with Cardiovascular Diseases

@article{Duchin1988PharmacokineticsOC,
  title={Pharmacokinetics of Captopril in Healthy Subjects and in Patients with Cardiovascular Diseases},
  author={Kenneth L. Duchin and DORIS N. Mckinstry and Albert Cohen and Bruce H. Migdalof},
  journal={Clinical Pharmacokinetics},
  year={1988},
  volume={14},
  pages={241-259}
}
SummaryCaptopril, the first orally active inhibitor of angiotensin-converting enzyme, is used widely in the treatment of hypertension and congestive heart failure. The pharmacokinetics of this agent have been studied extensively in healthy subjects and in patients with hypertension, congestive heart failure, and chronic renal failure. Captopril contains a sulphydryl group and binds readily to albumin and other plasma proteins. The drug also forms mixed disulphides with endogenous thiol… 

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