Pharmacokinetics of Alpha‐Lipoic Acid in Subjects With Severe Kidney Damage and End‐Stage Renal Disease

@article{Teichert2005PharmacokineticsOA,
  title={Pharmacokinetics of Alpha‐Lipoic Acid in Subjects With Severe Kidney Damage and End‐Stage Renal Disease},
  author={J. Teichert and Tina Tuemmers and H. Achenbach and C. Preiss and R. Hermann and P. Ruus and R. Preiss},
  journal={The Journal of Clinical Pharmacology},
  year={2005},
  volume={45}
}
In an open‐label, parallel‐group study involving 16 patients (8 with severely reduced renal function, 8 with end‐stage renal disease needing hemodialysis), the effect of renal function on the pharmacokinetics, metabolism, and safety and of alpha‐lipoic acid (thioctic acid) was evaluated by comparing the pharmacokinetic parameters with those of a reference group of 8 healthy subjects. Alpha‐lipoic acid 600 mg was administered orally once daily for 4 days, and the pharmacokinetic parameters were… Expand
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