Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.

@article{Schinazi1990PharmacokineticsO3,
  title={Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.},
  author={Raymond F Schinazi and F. Douglas Boudinot and Kokila Doshi and H. M. Mcclure},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 6},
  pages={
          1214-9
        }
}
3'-Fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine are nucleoside analogs which inhibit human and simian immunodeficiency virus in vitro. The pharmacokinetic properties of these compounds in rhesus monkeys after intravenous, oral, and subcutaneous administration of the drug were compared. Half-lives, total clearances, and steady-state volumes of distribution of the two drugs were determined. The half-lives for the drugs by the different routes were between 0.58 and 1.4 h. Oral… CONTINUE READING

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A simplified analysis of [18F]3′-deoxy-3′-fluorothymidine metabolism and retention

  • European Journal of Nuclear Medicine and Molecular Imaging
  • 2005
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CITES BACKGROUND

Toxicokinetics of 2',3'-didehydro-3'-deoxythymidine, stavudine (D4T).

  • Drug metabolism and disposition: the biological fate of chemicals
  • 1999
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CITES RESULTS & BACKGROUND