Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor doses.

@article{Muindi2004PharmacokineticsO1,
  title={Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor doses.},
  author={Josephia R. Muindi and Ruth A. Modzelewski and Yibing Peng and Donald L. Trump and Candace S. Johnson},
  journal={Oncology},
  year={2004},
  volume={66 1},
  pages={62-6}
}
OBJECTIVES Calcitriol, 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3)) has potent antiproliferative effects and potentiates the antitumor activity of many other cytotoxic drugs. 1,25-D(3) plasma pharmacokinetic (PK) parameters associated with antitumor activity in experimental animal models are unknown. The objective of this study was to determine plasma calcitriol PK in normal mice at doses of calcitriol which are active in suppressing tumor growth. METHODS Plasma 1,25-D(3) PK were examined in… CONTINUE READING