Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation.

  title={Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation.},
  author={Steve N. Caritis and Shringi Sharma and Raman Venkataramanan and Dwight J. Rouse and Alan M. Peaceman and Anthony C. Sciscione and Catherine Y. Spong and Michael W. Varner and Fergal Desmond Malone and Jay D. Iams and Brian M. Mercer and John M Thorp and Yoram Sorokin and Marshall W J Carpenter and Julie Y Lo and Susan Marie Ramin and Margaret Harper},
  journal={American journal of obstetrics and gynecology},
  volume={205 1},
OBJECTIVE The purpose of this study was to define the pharmacokinetic parameters of 17-hydroxyprogesterone caproate (17-OHPC) in multifetal gestation. STUDY DESIGN Blood was obtained at 24-28 weeks' gestation and at 32-35 weeks gestation in 97 women with twin and 26 women with triplet gestation who were receiving 17-OHPC. Six of the women with twins had daily blood sampling for 7 days between 24 and 28 weeks' gestation, and pharmacokinetic parameters were estimated with the use of… CONTINUE READING

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