Pharmacokinetics of (+)-rolipram and (−)-rolipram in healthy volunteers

@article{Krause2004PharmacokineticsO,
  title={Pharmacokinetics of (+)-rolipram and (−)-rolipram in healthy volunteers},
  author={Werner Krause and G. K{\"u}hne and N. Sauerbrey},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={38},
  pages={71-75}
}
SummaryPlasma levels of S-(+)-rolipram and R-(−)-rolipram in six healthy male volunteers were measured by radioimmunoassay after intravenous injection of 0.1 mg and oral administration of 1.0 mg of the pure enantionmers. Following i.v. treatment, plasma levels of both isomers declined in three phases, with half-lives of 0.2 h, 0.6–0.9 h and 6–8 h. Total clearance was 6 ml · min−1 · kg−1. Oral administration of 1.0 mg gave a peak concentration of 16 ng · ml−1 after 0.5 h. Bioavailability of… Expand

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