Pharmacokinetics in pregnancy and placental drug transfer.

  title={Pharmacokinetics in pregnancy and placental drug transfer.},
  author={F. Fisher Reynolds and Charles Knott},
  journal={Oxford reviews of reproductive biology},
Total body water increases in pregnancy and while the uterus, placenta, fetus, and amniotic fluid constitute part of this increase, the largest component is in the extracellular water. Fat stores also increase and thus the distribution volumes of all drugs expand, but the major effect is seen in polar drugs which are confined to the extracellular space. Cardiac output and renal function also increase and elimination of polar drugs is accelerated. In contrast, the elimination of lipophilic drugs… CONTINUE READING


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