Pharmacokinetics in clinical practice. I. Concepts.

@article{Gibaldi1976PharmacokineticsIC,
  title={Pharmacokinetics in clinical practice. I. Concepts.},
  author={Milo Gibaldi and Gerhard Levy},
  journal={JAMA},
  year={1976},
  volume={235 17},
  pages={1864-7}
}
Important concepts of pharmacokinetics, such as the biologic half-life, clearance, and bioavailability of drugs, can be utilized to describe and predict the time course of drug concentrations in plasma as a function of dose and frequency of drug administration. In quantitative terms, they can serve to characterize the individuality of the patient, including… CONTINUE READING