Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4.

@article{Yu2016PharmacokineticsIV,
  title={Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4.},
  author={Zongjiang Yu and Weizhi Sun and Weibing Peng and Rilei Yu and Guoqiang Li and Tao Jiang},
  journal={Molecular pharmaceutics},
  year={2016},
  volume={13 5},
  pages={1699-710}
}
Oleanolic acid (OA) is a well-known pentacyclic triterpenoid compound, which has been used as a dietary supplement and is supplied as an over-the-counter drug for the treatment of human liver diseases. These are reasons for the low bioavailability of OA which have restricted its wider application. In this study, two OA prodrugs (1,3-cyclic propanyl phosphate esters of OA) were designed and synthesized. The hepatoprotective effects of these prodrugs were evaluated against carbon tetrachloride… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Naringin prevents carbon tetrachloride-induced acute liver injury in mice

D. S. Dong, L. Xu, L. H. Yin, Y. Qi, J. Y. Peng
J. Funct. Foods • 2015

Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: Formulation optimization, characterization, oral bioavailability and tissue distribution in rats.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2015

Gynostemma pentaphyllum extract in rat serum, urine and faeces after oral administration

M. S. Abdel-Bakky, G. K. Helal, E. M. El-Sayed, A. S. Saad
J. Chromatogr. B • 2014

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