Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children.

@article{Kalso1994PharmacokineticsAV,
  title={Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children.},
  author={Eija Kalso},
  journal={British journal of clinical pharmacology},
  year={1994},
  volume={38 1},
  pages={71-6}
}
  • Eija Kalso
  • Published 1994 in British journal of clinical pharmacology
1. Oxycodone hydrochloride (0.1 mg kg-1) was given by intravenous bolus to 18 children after ophthalmic surgery. Plasma was sampled for up to 8 h. Blood pressure, heart rate, peripheral arteriolar oxygen saturation, end-tidal carbon dioxide and halothane concentrations and ventilatory rate were also recorded. 2. Mean (+/- s.d.) values of drug clearance and volume of distribution (Vss) were 15.2 +/- 4.2 ml min-1 kg-1 and 2.1 +/- 0.8 l kg-1. Maximum mean end-tidal carbon dioxide concentration and… CONTINUE READING