Pharmacokinetics and toxicity testing.

  title={Pharmacokinetics and toxicity testing.},
  author={Brian L Clark and Dennis A. Smith},
  journal={Critical reviews in toxicology},
  volume={12 4},
The pharmacokinetic basis for the design of toxicity tests is discussed with reference to the absorption and clearance of drugs. The absorption and clearance of a wide range of drugs by laboratory animals and man has been examined and reviewed to provide a firm basis against which new drugs can be compared. Some pitfalls in either the empirical approach to toxicology or the incorrect interpretation of kinetic data are highlighted. An approach is outlined for the rational application of animal… CONTINUE READING

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