Pharmacokinetics and toxic effects of lithium chloride after intravenous adminstration in conscious horses.

@article{Hatfield2001PharmacokineticsAT,
  title={Pharmacokinetics and toxic effects of lithium chloride after intravenous adminstration in conscious horses.},
  author={Cindy L Hatfield and W. N. Mcdonell and Kip A Lemke and William D. Black},
  journal={American journal of veterinary research},
  year={2001},
  volume={62 9},
  pages={1387-92}
}
OBJECTIVE To determine the pharmacokinetics and toxic effects associated with IV administration of lithium chloride (LiCl) to conscious healthy horses. ANIMALS 6 healthy Standardbred horses. PROCEDURE Twenty 3-mmol boluses of LiCl (0.15 mmol/L) were injected IV at 3-minute intervals (total dose, 60 mmol) during a 1-hour period. Blood samples for measurement of serum lithium concentrations were collected before injection and up to 24 hours after injection. Behavioral and systemic toxic… CONTINUE READING