Pharmacokinetics and tolerance study of intravitreal injection of dexamethasone-loaded nanoparticles in rabbits

@inproceedings{Zhang2009PharmacokineticsAT,
  title={Pharmacokinetics and tolerance study of intravitreal injection of dexamethasone-loaded nanoparticles in rabbits},
  author={Linhua Zhang and Yue Li and Chao Zhang and Yu-sheng Wang and Cunxian Song},
  booktitle={International journal of nanomedicine},
  year={2009}
}
The aim of the study was to investigate the tolerance and pharmacokinetics of dexamethasone (DEX)-loaded poly(lactic acid-co-glycolic acid) nanoparticles (DEX-NPs) in rabbits after intravitreal injection. The DEX-NPs were prepared and characterized in terms of morphology, particle size and size distribution, encapsulation efficiency, and in vitro release. Ophthalmic investigations were performed, including fundus observation and photography, intraocular pressure measurement, and B-scan ocular… CONTINUE READING

9 Figures & Tables

Connections & Topics

Mentioned Connections BETA
The DEX concentrations in plasma and the ocular tissues such as the cornea , aqueous humor , lens , iris , vitreous humor , and chorioretina were determined by high - pressure liquid chromatography .
The DEX concentrations in plasma and the ocular tissues such as the cornea , aqueous humor , lens , iris , vitreous humor , and chorioretina were determined by high - pressure liquid chromatography .
All Topics