Pharmacokinetics and tolerance of single- and multiple-dose oral or intravenous linezolid, an oxazolidinone antibiotic, in healthy volunteers.

@article{Stalker2003PharmacokineticsAT,
  title={Pharmacokinetics and tolerance of single- and multiple-dose oral or intravenous linezolid, an oxazolidinone antibiotic, in healthy volunteers.},
  author={Dennis J. Stalker and Gail L Jungbluth and Nancy K Hopkins and Donald H Batts},
  journal={The Journal of antimicrobial chemotherapy},
  year={2003},
  volume={51 5},
  pages={1239-46}
}
AIMS To determine the pharmacokinetics and tolerance of oral and intravenous linezolid, an oxazolidinone antibiotic, in healthy volunteers following single- and multiple-dose administration. METHODS In two randomized, double-blind, placebo-controlled, dose-escalating trials, subjects were exposed either to oral (375, 500 or 625 mg) or intravenous (500 or 625 mg) linezolid or placebo twice daily. Serial blood and urine samples were obtained after the first- and multiple-dose administrations… CONTINUE READING