Pharmacokinetics and tissue localization of doxycycline polyphosphate and doxycycline hydrochloride in the rat

@article{Michel2010PharmacokineticsAT,
  title={Pharmacokinetics and tissue localization of doxycycline polyphosphate and doxycycline hydrochloride in the rat},
  author={G. Michel and J. Mosser and John M. Olle},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={9},
  pages={149-153}
}
  • G. Michel, J. Mosser, J. Olle
  • Published 1 April 1984
  • Chemistry, Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
SummaryTwo doxycycline derivatives Doxycycline polyphosphate and Doxycycline hydrochloride were administered to rats at a dose of 20 mg/kg body weight. Doxycycline tissue levels were determined using a microbiological assay.Only an insignificant fraction of the antibiotics was found to cross the blood brain barrier. Doxycycline was highly concentrated in excretory organs: liver, kidneys and caecum. The high intestinal drug level observed is probably related to the entero-hepatic cycle of this… 
Pharmacokinetics of pradofloxacin and doxycycline in serum, saliva, and tear fluid of cats after oral administration.
TLDR
The high concentrations of pradofloxacin in saliva and tear fluid are promising to apply prad ofloxAcin for the treatment of conjunctivitis and upper respiratory tract infections in cats, as doxycycline is barely secreted into these fluids after oral application the mechanisms of its clinical efficacy remain unclear.
Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis.
TLDR
In vitro studies surprisingly revealed that doxycycline was effective at inhibiting the efflux of ivermectin and doramectin (minocycline had no effect), and these two avermectins, in combination with doxy cycline, should be considered when treating meningeal worms in alpacas.
Use of a Monte Carlo analysis within a physiologically based pharmacokinetic model to predict doxycycline residue withdrawal time in edible tissues in swine
TLDR
It is illustrated that MC analysis can be incorporated into the PBPK model to accurately predict doxycycline residue withdrawal time in edible tissues in swine.
Untersuchung der Konzentrationen von Pradofloxacin und Doxycyclin in Serum, Tränen- und Speichelflüssigkeit bei Katzen und Prüfung der Wirksamkeit von Pradofloxacin im Vergleich zu Doxycyclin bei Katzenschnupfen und Infektionen mit Chlamydophila felis und Mykoplasmen
TLDR
The high concentrations of pradofloxacin in saliva and tear fluid are promising to apply prad oflOxacin for the treatment of conjunctivitis and upper respiratory tract infections in cats, as doxycycline is barely secreted into these fluids after oral application the mechanism of its clinical efficacy remain unclear.
The abdominal skin of female Sprague-Dawley rats is more sensitive than the back skin to drug-induced phototoxicity.
TLDR
The abdominal skin is more sensitive to drug-induced phototoxic than the back skin and may represent a preferable site for irradiation in this rat phototoxicity model.
Tet system in the brain: Transgenic rats and lentiviral vectors approach
TLDR
Combination of rat transgenesis and lentiviral vectors is a novel approach enabling precise spatiotemporal regulation of genes of interest strictly in the brain structure of choice or in other tissues.
Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice
The hexanucleotide G4C2 repeat expansion in the first intron of the C9ORF72 gene explains the majority of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) cases. Numerous studies
Inducible expression of human C9ORF72 36× G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice
TLDR
Only 36 C9ORF72 repeats are sufficient for RAN translation in a new mouse model for amyotrophic lateral sclerosis and frontotemporal dementia, which suggests that early diagnosis and treatment are important for C9FTD/ALS patients.
Liquid Chromatography-Tandem Mass Spectrometry Determination and Depletion Profile of Chlortetracycline, Doxycycline, and Oxytetracycline in Broiler Chicken Muscle After Oral Administration
A simple and fast method based on liquid chromatography–electrospray ionization-tandem mass spectrometry (LC–ESI-MS/MS) was developed and validated for determination of tetracyclines in broiler
A Sox10rtTA/+ Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear
TLDR
The utility of the Sox10rtTA/+ mouse line is highlighted as a powerful tool for functional genetic studies of the auditory and balance organs in vivo, but also some important considerations that must be adequately controlled for in future studies that rely upon Tet-On/Off systems are revealed.

References

SHOWING 1-10 OF 27 REFERENCES
Bioavailability of Tetracycline and Doxycycline in Fasted and Nonfasted Subjects
The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human
The Disposition of Doxycycline by Man and Dog
The disposition of doxycycline by man and dog was investigated with the aid of labeled drug. Isotope dilution methods were instrumental in the successful identification of fecal excretion products.
Doxycycline pharmacokinetics in the absence of renal function.
TLDR
It is demonstrated that in anephric patients and patients with varying degrees of renal function the plasma t½ of biologically active doxycycline is not significantly extended and that in such a clinical situation the usual therapeutic regimen of the drug is necessary.
The disposition of doxycycline by the rat.
TLDR
Doxycycline passes relatively easily through the intestinal wall and is less dependent upon normal renal function for its elimination than other tetracyclines of lesser lipophilicity, which helps explain the clinical observation that doxycycline unlike other tributaries does not accumulate in patients with renal insufficiency.
Doxycycline in serum and bronchial secretions.
TLDR
The clinical efficacy of doxycycline does not appear to be related to sputum concentration, although the progressive increase in sputUM doxy cycline levels may be relevant in preventing recurrence of acute infection when the drug is administered as long-term prophylactic therapy.
Protein Binding of Antimicrobials: Clinical Pharmacokinetic and Therapeutic Implications
TLDR
Tissue and extravascular fluid drug levels are primarily influenced by the free drug levels in serum, but calculation of actual tissue levels is complicated by variable binding characteristics of specific tissues and tissue fluids, and also by the lipophilic nature of the drug.
The distribution of tetracyclines in tissues of dogs after repeated oral administration.
TLDR
It was found that the distribution of the antibiotics between tissue depots and interstitial fluid correlates well with the partition coefficients in chloroform and water, a measure of the lipid solubilities of the compounds.
The excretion and distribution in body fluids of tetracyclines after intravenous administration to dogs.
6-Methyleneoxytetracycline, MOTC (methacycline), was studied in dogs after intravenous administration and compared with 6-demethyl-chlortetracycine, DMCT (Declomycin), α-6-deoxyoxytetracycline,
Theory and practical impact of binding of antimicrobials to serum proteins and tissue.
  • W. Craig, B. Suh
  • Medicine
    Scandinavian journal of infectious diseases. Supplementum
  • 1978
Binding of antimicrobials to serum proteins and tissue affects their distribution, elimination and antimicrobial activity. Penetration of drugs into most tissues and interstitial and inflammatory
Visualization of doxycycline in lung tissue and sinus secretions by fluorescent techniques.
The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus
...
1
2
3
...