Pharmacokinetics and tissue distribution of uraemic indoxyl sulphate in rats.

  title={Pharmacokinetics and tissue distribution of uraemic indoxyl sulphate in rats.},
  author={Tsuneo Deguchi and Mikio Nakamura and Yasuhiro Tsutsumi and Ayaka Suenaga and Masaki Otagiri},
  journal={Biopharmaceutics & drug disposition},
  volume={24 8},
The purpose of the present study was to examine the pharmacokinetic properties of indoxyl sulphate, a harmful uraemic toxin that accumulates during chronic renal failure. The pharmacokinetics and tissue distribution of indoxyl sulphate were examined in normal and 5/6 nephrectomized (CRF) rats. The uptake process of indoxyl sulphate by rat renal cortical slices in vitro was also investigated. Endogenous indoxyl sulphate was found to be mainly distributed in the kidney. The rate of elimination of… CONTINUE READING


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