Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog.

@article{Leusch2001PharmacokineticsAT,
  title={Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog.},
  author={Andreas Leusch and Bettina Eichhorn and Gabriele M{\"u}ller and Karl L. Rominger},
  journal={Biopharmaceutics & drug disposition},
  year={2001},
  volume={22 5},
  pages={199-212}
}
Ipratropium, a current treatment for chronic obstructive pulmonary disease (COPD) and tiotropium, a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine. In this study, the intravenous (i.v.), oral (p.o.) and intratracheal (i.tr.) single dose pharmacokinetics (PK) of tiotropium and ipratropium were determined in rat and dog. In rats, concentration-time profiles of tiotropium and ipratropium after single i.v. bolus administration of… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
single dose pharmacokinetics ( PK ) of tiotropium and ipratropium were determined in rat and dog .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
In rats , concentration - time profiles of tiotropium and ipratropium after single i.v .
Both ipratropium and tiotropium showed a comparable terminal elimination half - life in rat urine ( 21 - 24 h ) after single i.v .
Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog .
Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog .
Both ipratropium and tiotropium showed a comparable terminal elimination half - life in rat urine ( 21 - 24 h ) after single i.v .
In rats , concentration - time profiles of tiotropium and ipratropium after single i.v .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
single dose pharmacokinetics ( PK ) of tiotropium and ipratropium were determined in rat and dog .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
Ipratropium , a current treatment for chronic obstructive pulmonary disease ( COPD ) and tiotropium , a longer acting anticholinergic bronchodilator currently being developed for COPD are structurally related to atropine .
All Topics