Pharmacokinetics and tissue distribution of amoxicillin in healthy and Salmonella Typhimurium-inoculated pigs.

@article{Agers2000PharmacokineticsAT,
  title={Pharmacokinetics and tissue distribution of amoxicillin in healthy and Salmonella Typhimurium-inoculated pigs.},
  author={Henrik Agers\o and Christian Friis and Jens Peter Nielsen},
  journal={American journal of veterinary research},
  year={2000},
  volume={61 8},
  pages={992-6}
}
OBJECTIVE To determine pharmacokinetics and tissue distribution of amoxicillin in healthy and Salmonella Typhimurium-inoculated pigs. ANIMALS 12 healthy pigs and 12 S Typhimurium-inoculated pigs. PROCEDURE Concentration of amoxicillin in tissue was measured by use of high-performance liquid chromatography 4, 8, 12, and 24 hours after IM administration. Pharmacokinetic values of amoxicillin in plasma were assessed by use of a 1-compartment model with first-order absorption. RESULTS… CONTINUE READING