Pharmacokinetics and tissue distribution of minocycline hydrochloride in horses.

@article{Nagata2010PharmacokineticsAT,
  title={Pharmacokinetics and tissue distribution of minocycline hydrochloride in horses.},
  author={Shun-ichi Nagata and Shozo Yamashita and Masahiko Kurosawa and Masao Kuwajima and Seiji Hobo and Yoshinari Katayama and Toru Anzai},
  journal={American journal of veterinary research},
  year={2010},
  volume={71 9},
  pages={1062-6}
}
OBJECTIVE To determine the pharmacokinetics and tissue distribution of minocycline in horses. ANIMALS 5 healthy Thoroughbred mares for the pharmacokinetic experiment and 6 healthy Thoroughbred mares for the tissue distribution experiment. PROCEDURES Each mare was given 2.2 mg of minocycline hydrochloride/kg, IV. Blood samples were collected once before minocycline administration (0 hours) and 10 times within 48 hours after administration in the pharmacokinetics study, and 24 tissue samples… CONTINUE READING

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