Pharmacokinetics and thrombolytic effects of the recombinant tissue-type plasminogen activator in horses

Abstract

BACKGROUND To test the efficacy of the recombinant tissue-type plasminogen activator (rt-PA) alteplase in horses, the thrombolytic effect was tested in in vitro generated equine thrombi. The extent of lysis was determined by measuring the decrease in thrombi weight over a period of 4 hours. In vivo pharmacokinetics of alteplase were determined in 6 healthy… (More)
DOI: 10.1186/1746-6148-9-158

Topics

4 Figures and Tables