Pharmacokinetics and subjective effects of sublingual buprenorphine, alone or in combination with naloxone: lack of dose proportionality.

@article{Harris2004PharmacokineticsAS,
  title={Pharmacokinetics and subjective effects of sublingual buprenorphine, alone or in combination with naloxone: lack of dose proportionality.},
  author={Debra S. Harris and John E. Mendelson and Emil T. Lin and Robert A. Upton and Reese Jones},
  journal={Clinical pharmacokinetics},
  year={2004},
  volume={43 5},
  pages={
          329-40
        }
}
OBJECTIVE Buprenorphine and buprenorphine/naloxone combinations are effective pharmacotherapies for opioid dependence, but doses are considerably greater than analgesic doses. Because dose-related buprenorphine opioid agonist effects may plateau at higher doses, we evaluated the pharmacokinetics and pharmacodynamics of expected therapeutic doses. DESIGN The first experiment examined a range of sublingual buprenorphine solution doses with an ascending dose design (n = 12). The second… CONTINUE READING
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