Pharmacokinetics and sputum penetration of ciprofloxacin in patients with cystic fibrosis.

  title={Pharmacokinetics and sputum penetration of ciprofloxacin in patients with cystic fibrosis.},
  author={Michael J. Smith and Les O. White and H Bowyer and Jennifer Willis and Margaret E. Hodson and J C Batten},
  journal={Antimicrobial agents and chemotherapy},
  volume={30 4},
Levels of ciprofloxacin in serum and sputum were studied for eight patients with cystic fibrosis who were infected with Pseudomonas aeruginosa. Patients were studied in a steady state on a dosage of 500 mg every 8 h. Peak levels in serum ranged from 1.27 to 5.6 mg/liter (mean, 3.16 +/- 1.27), and absorption was rapid, the time to peak concentration ranging from 0.5 to 3.0 h (mean, 1.5 +/- 0.9). The antibiotic penetrated sputum well, achieving areas under the curve of approximately 46% of those… CONTINUE READING

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