Pharmacokinetics and side-effects of clonazepam and its 7- amino-metabolite in man

@article{Sj2004PharmacokineticsAS,
  title={Pharmacokinetics and side-effects of clonazepam and its 7- amino-metabolite in man},
  author={O. Sj{\"o} and E. Hvidberg and J. Naestoft and M. Lund},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={8},
  pages={249-254}
}
SummaryClonazepam (CNP) and its principal metabolite in plasma, 7-amino-CNP (ACNP), have been investigated in a prospective study of 27 newly diagnosed epileptics and correlated with specified side-effects. At a daily dose of 6 mg, the average plasma levels of both substances were about 50ng/ml, and individual values ranged from 30 to about 80ng/ml. There was a linear correlation between changes in dose and the resulting plasma levels, which indicates first order elimination kinetics. Side… Expand
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