Pharmacokinetics and serum bactericidal activity of ticarcillin and clavulanic acid.

@article{Hoeffken1985PharmacokineticsAS,
  title={Pharmacokinetics and serum bactericidal activity of ticarcillin and clavulanic acid.},
  author={Gert Hoeffken and H Tetzel and P. Koeppe and Hartmut M Lode},
  journal={The Journal of antimicrobial chemotherapy},
  year={1985},
  volume={16 6},
  pages={763-71}
}
The pharmacokinetics of ticarcillin 5.0 g and clavulanic acid 0.2 g were examined both alone and combined (3.0 or 5.0 g ticarcillin + 0.2 g clavulanic acid as 3.2 or 5.2 g timentin) after a 15 min infusion in ten healthy volunteers. At the same time, the serum bactericidal activity of 5.0 g ticarcillin alone and 5.2 g Timentin was determined against two ticarcillin resistant strains each of Klebsiella oxytoca and Pseudomonas aeruginosa in the first and sixth hour after administration. The serum… CONTINUE READING

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