Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants.

@article{Flynn2011PharmacokineticsAS,
  title={Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants.},
  author={Patricia M. Flynn and Mark M Mirochnick and David E Shapiro and Arlene D. Bardeguez and John S Rodman and Brian Robbins and Sharon A Huang and Susan A. Fiscus and Koen K A Van Rompay and James F. Rooney and Brian Kearney and Lynne Mofenson and D Heather Watts and Patrick Jean-Philippe and Barbara E Heckman and Edwin M. Thorpe and Amanda Cotter and Murli Purswani},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 12},
  pages={5914-22}
}
Tenofovir (TFV) is effective in preventing simian immunodeficiency virus (SIV) transmission in a macaque model, is available as the oral agent tenofovir disoproxil fumarate (TDF), and may be useful in the prevention of mother-to-child transmission of human immunodeficiency virus (HIV). We conducted a trial of TDF and TDF-emtricitabine (FTC) in HIV-infected pregnant women and their infants. Women received a single dose of either 600 mg TDF, 900 mg TDF, or 900 mg TDF-600 mg FTC at labor onset or… CONTINUE READING
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