Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms

@article{Harrison2004PharmacokineticsAS,
  title={Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms},
  author={Lester I Harrison and Shari L. Skinner and Thomas C. Marbury and Mary L. Owens and Sarala Kurup and Scott McKane and Robert J. Greene},
  journal={Archives of Dermatological Research},
  year={2004},
  volume={296},
  pages={6-11}
}
The safety and efficacy of imiquimod 5% cream is being evaluated for the treatment of dysplastic lesions of the epidermis (actinic keratoses, AK). The objective of this clinical study was to describe the pharmacokinetics and safety of topical imiquimod during multiple dosing of AK subjects. A total of 58 adult subjects with 5 to 20 AK lesions at the treatment site applied imiquimod cream three times per week for up to 16 weeks as follows: 12 males and 11 females applied 12.5 mg imiquimod to the… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Pharmacokinetics of imiquimod 3.75% cream applied daily for 3 weeks to actinic keratoses on the face and/or balding scalp

  • Archives of Dermatological Research
  • 2010
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Topical Imiquimod

VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Basic pharmacology of topical imiquimod, 5-fluorouracil, and diclofenac for the dermatologic surgeon.

  • Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2012
VIEW 1 EXCERPT
CITES METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 18 REFERENCES

Imiquimod: A Review

  • Journal of cutaneous medicine and surgery
  • 2002

Side effects of therapy of hepatitis C and their management

MW Fried
  • Hepatol
  • 2002