Pharmacokinetics and safety of glimepiride at clinically effective doses in diabetic patients with renal impairment

@article{Rosenkranz1996PharmacokineticsAS,
  title={Pharmacokinetics and safety of glimepiride at clinically effective doses in diabetic patients with renal impairment},
  author={Bernd Rosenkranz and Velimir Profozi{\'c} and Željko Metelko and V. Mrzljak and Conrad Lange and Vitus Malerczyk},
  journal={Diabetologia},
  year={1996},
  volume={39},
  pages={1617-1624}
}
The pharmacokinetics, efficacy and safety of glimepiride were investigated in a single- and a multiple-dose open study in patients with non-insulin-dependent diabetes mellitus and renal impairment and an initial creatinine clearance above 10 ml/min. Patients were divided into three groups with creatinine clearance above 50 ml/min, 20–50 ml/min and under 20 ml/min. Fifteen fasting patients received a single dose of 3 mg glimepiride and serial blood and urine samples were taken over 24 h for… CONTINUE READING

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The pharmacokinetics , efficacy and safety of glimepiride were investigated in a single- and a multiple - dose open study in patients with non - insulin - dependent diabetes mellitus and renal impairment and an initial creatinine clearance above 10 ml / min .
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