Pharmacokinetics and renal clearance of oxytetracycline in piglets following intravenous and oral administration.

@article{Mevius1986PharmacokineticsAR,
  title={Pharmacokinetics and renal clearance of oxytetracycline in piglets following intravenous and oral administration.},
  author={Dik J. Mevius and L. Vellenga and Henk J. Breukink and J. F. M. Nouws and Tom B. Vree and F. C. M. Driessens},
  journal={The Veterinary quarterly},
  year={1986},
  volume={8 4},
  pages={274-84}
}
The pharmacokinetics of oxytetracycline (OTC) in three weaned piglets was studied following three routes of administration: intravenously, orally as drench, both at a dose of 20 mg/kg, and orally as medicated (400 ppm OTC) pelleted feed administered during 3 consecutive days. Analysis of the intravenous data according to the three compartment pharmacokinetic model revealed that OTC was well distributed in the body (Vf: 1.62 l/kg), had an overall body clearance of 0.25 litre/kg/h, and the… CONTINUE READING

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