Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man

  title={Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man},
  author={D. D. Breimer and Albertus G. de Boer},
  journal={European Journal of Clinical Pharmacology},
  • D. Breimer, A. D. Boer
  • Published 19 December 1975
  • Medicine, Chemistry, Biology
  • European Journal of Clinical Pharmacology
SummaryA method has been developed for the quantitative determination of heptabarbital [5-(1-cyclohepten-1-yl)-5-ethylbarbituric acid] in human plasma after administration of single therapeutic doses of the drug. It involves a single extraction step followed by gas chromatography with alkali flame ionization detection, and the results were linear in the concentration range 0.125 – 5.0 µg/ml plasma. The pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium were… 
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